About Me

You got a dream, you gotta protect it. People can't do something themselves they wanna tell you, you can't do it. If you want something, go get it.
- The Pursuit of Happiness.

My Name is Kai Gu

Graduated from Zhejiang University of Technology, majoring in Biochemistry.
For personal interest, I chose Bioinformatics by self-learning at my first job in a biotech in 2016. With the purpose of knowing more about clinical research or trial, I went to one IVD company as a statistical analyst and bio-statistician for the clinical trial of Reagent later...

Purpose

The first purpose for writing blogs is to push myself to learn the knowledge of Bioinformatics as I'm interprofessional so I need to learn more and faster to reach the higher grade.
Also I like to keep notes and share any ideas in work and interest fields.

Contact

Email:
gukai1212@163.com
Github:
https://github.com/kaigu1990
Blog:
https://www.bioinfo-scrounger.com
Location:
ShangHai, China

Profession

Bioinformatics

Lets me know what is the interdisciplinary Biology and Computer, and how to use programming and statistical method to resolve questions.
The precious research experience teaches me how to conduct a basic research, such as posing a question and exploring it.

Statistical Programmer

Lets me know what is the clinical data in the submission stage of clinical trial, and how to handle it through the programming by SAS & R.
Building maintainable and robust R packages as well as Shiny modules with the tech stack in the multi-collaboration mode.

Bio-statistician

Lets me know what is the clinical protocol, and the role and responsibilities as a bio-statistician in the clinical trial.
Learning more statistical methods and designs in the clinical trial.
How to conduct a clinical from a bio-statistician perspective.

Interest

Programming

Statistical Method

Data Visualization

Machine Learning

Conclusion

The ending of my career is unknown.
I'm not a smart person, however, I can learn quickly and always do my best.

“We live and learn, or, perhaps more importantly we learn and live.”
— Terry Pratchett

Publications

My published collaborative research, to date. Just a few work inside.

Wei Nie, Mi-Die Xu, Lu Gan, Yi Zhang, Jie Qian, Kai Gu, Xue-Yan Zhang,... & Bao-Hui Han (2019) Advanced Non-Small Cell Lung Cancer Patients With Low Tumor Mutation Burden Might Derive Benefit From Immunotherapy, J Immunother 43(6):189-195 [PMID: 32209830]

Wei Nie, Jie Qian, Mi-Die Xu, Kai Gu, Fang-Fei Qian,... & Bao-Hui Han (2020) Prognostic and Predictive Value of Blood Tumor Mutational Burden in Patients With Lung Cancer Treated With Docetaxel, JNCCN 18(5):582-589 [PMID: 32380463]

Wei Nie, Jie Qian, Mi-Die Xu, Kai Gu, Fang-Fei Qian,... & Bao-Hui Han (2020) A non-linear association between blood tumor mutation burden and prognosis in NSCLC patients receiving atezolizumab, Oncoimmunology 9(1):1731072 [PMID: 32158623]

Wei Nie, Lu Gan, Xin Wang, Kai Gu, Fang-Fei Qian,... &Bao-Hui Han (2021) Atezolizumab prolongs overall survival over docetaxel in advanced non-small-cell lung cancer patients harboring STK11 or KEAP1 mutation, Oncoimmunology 10(1):1865670 [PMID: 33537171]

Shixiang Wang, Yi Xiong, Kai Gu, Longfei Zhao, Yin Lia, Fei Zhao, Xuejun Li, Xue-Song Liu (2021) UCSCXenaShiny: an R package for exploring and analyzing UCSC Xena public datasets in web browser, Bioinformatics. [PMID: 34323947] DOI: 10.1093/bioinformatics/btab561

Anning Xiong, Wei Nie, Yan Zhou, Changhui Li, Kai Gu, Ding Zhang,…& Xueyan Zhang (2021) Comutations in DDR Pathways Predict Atezolizumab Response in Non-Small Cell Lung Cancer Patients, Front. Immunol. 12:708558. doi: 10.3389/fimmu.2021.708558